Pregnancy Tests: Diagnostic pregnancy checks according to immunological reactions among HCG and anti-HCG may well cause Untrue-destructive or Wrong-positive interpretations.
Excessively substantial dosages of antihistamines, which includes promethazine hydrochloride, in pediatric sufferers may well cause sudden death (see OVERDOSAGE). Hallucinations and convulsions have occurred with therapeutic doses and overdoses of promethazine hydrochloride in pediatric sufferers. In pediatric sufferers that are acutely sick affiliated with dehydration, There's an elevated susceptibility to dystonias with using promethazine HCl.
Antiemetics are usually not suggested for therapy of uncomplicated vomiting in pediatric sufferers, as well as their use ought to be limited to prolonged vomiting of identified etiology. The extrapyramidal symptoms which may come about secondary to Promethazine HCl Oral Remedy administration may very well be puzzled While using the CNS signs of undiagnosed Principal sickness, e.g., encephalopathy or Reye's syndrome. The use of Promethazine HCl Oral Remedy need to be prevented in pediatric individuals whose signals and signs may well advise Reye's syndrome or other hepatic diseases.
Promethazine has an elimination fifty percent-lifetime of 10-fourteen several hours, with excretion of metabolites appearing from the urine and feces. The sulfoxides of promethazine and N-demethylpromethazine tend to be the predominant metabolites appearing in the urine.
Promethazine and codeine might lead to marked drowsiness or may possibly impair the mental and/or Bodily abilities expected for the efficiency of potentially hazardous responsibilities, for example driving a motor vehicle or functioning machinery.
Enhanced force in your head (elevated intracranial pressure). Steer clear of the usage of Promethazine Hydrochloride and Codeine Phosphate Oral Solution In case you have a head harm or are actually explained to you have changes inside the tissue of the brain (Mind lesions) or elevated strain within your head.
As a result of identical pharmacologic Attributes, it really is sensible to expect identical possibility with concomitant usage of opioid cough medicines and benzodiazepines, other CNS depressants, or Liquor.
Promethazine HCl Oral Resolution could impair the psychological and/or physical qualities required for that general performance of doubtless hazardous jobs, including driving a car or truck or operating machinery. The impairment could possibly check here be amplified by concomitant usage of other central-anxious-procedure depressants for instance alcohol, sedatives/hypnotics (which include barbiturates), narcotics, narcotic analgesics, normal anesthetics, tricyclic antidepressants, and tranquilizers; hence such agents really should both be eradicated or offered in diminished dosage from the presence of promethazine HCl (see PRECAUTIONS – Details for Sufferers and Drug Interactions).
Promethazine is contraindicated in comatose states, and in persons regarded to get hypersensitive or to possess experienced an idiosyncratic reaction to promethazine or to other
There's no normal arrangement about certain pharmacological treatment method regimens for uncomplicated NMS.
Constrained information counsel that utilization of promethazine hydrochloride all through labor and shipping and delivery doesn't have an appreciable impact on the duration of labor or supply and would not raise the possibility of have to have for intervention within the new child.
Promethazine shouldn't be used in pediatric sufferers fewer than 2 years of age because of the probable for lethal respiratory melancholy.
Hire other supportive measures (which include oxygen and vasopressors) during the administration of circulatory shock and pulmonary edema as indicated. Cardiac arrest or arrhythmias will require advanced lifestyle-support approaches. Gastric emptying may be practical in removing unabsorbed drug.
Antihistamines are contraindicated for use in the remedy of lower respiratory tract signs including bronchial asthma.